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    Boundary Cap cells in development and disease


    Séminaire de l'Institut Cochin

    Mardi 2 octobre 2018 - 12h00 - Salle de conférence Rosalind Franklin, 2ème étage


    Piotr Topilko

    Inserm U368, Ecole Normale Supérieure, Paris, France


     invité par Evelyne Bloch-Gallego

    Institut Cochin, 22 rue Méchain, 75014 Paris



    Broad plasticity of the peripheral glia is an emerging concept during development of the peripheral nervous system (PNS). Recent studies, done by our team have identified the neural crest-derived boundary caps (BCs), as a multitask stem cell population of the developing PNS. BC progeny migrate along the nerves to provide the major glial component of nerve roots and nerve terminals and vasculature in the skin. Strikingly, those two locations constitute the privileged sites for development of benign peripheral nerve sheath tumors called neurofibromas in patients with Neurofibromatosis type 1 (NF1), making BCs attractive candidates for the “cell of origin” of this disease. I will review these exciting findings, focusing on the heterogeneity of BCs, their novel  functions of BCs and their implication in the pathogenesis of NF1.


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