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    Epigenetics: One genome, multiple phenotypes

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    SÉMINAIRE DE L'INSTITUT COCHIN

    Danny Reinberg
     

    Danny Reinberg

    Howard Hughes Medical Institute
    NYU Langone School of Medicine at Smilow Research Center,
    New York, USA

    Chair Blaise Pascal, Institut Curie, Paris

     

    Jeudi 14 septembre 2017 à 12h00

     

     invité par Julie Chaumeil

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

     

    Epigenetics encompasses changes in gene expression profiles that occur without alterations in the genomic DNA sequence of a cell. This arises from the dynamic processes that structure regions of chromosomal DNA through a range of compaction in eukaryotes. The altered pattern of gene expression is pivotal to cellular differentiation and development and is inherited by daughter cells thereby maintaining the integrity, specifications, and functions for a given cell type.  Aberrancies in this epigenetic process give rise to perturbations that are also inherited and disruptive to normal cellular properties. The histone proteins that package DNA into chromatin are subject to post-translational modifications generating different chromatin structures. The polycomb repressive complexes play pivotal functions in maintaining cellular identity through alteration of chromatin domains. Functions of these complexes will be discussed.

     

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