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    Beta cell heterogeneity and regeneration

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    SÉMINAIRE DE L'INSTITUT COCHIN

     Heiko Lickert

    Heiko Lickert

    Helmholtz Zentrum München, Neuherberg, Germany

     

    Jeudi 19 octobre 2017 à 12h00

     

     invité par Raphaël Scharfmann

     

    Institut Cochin, 22 rue Méchain, 75014 Paris
    Salle de conférence Rosalind Franklin, 2e étage

    Abstract:

    Although β‑cell heterogeneity was discovered more than 50 years ago, the underlying principles have been explored only during the past decade. Islet-cell heterogeneity arises during pancreatic development and might reflect the existence of distinct populations of progenitor cells and the developmental pathways of endocrine cells. Heterogeneity can also be acquired in the postnatal period owing to β‑cell plasticity or changes in islet architecture. Furthermore, β‑cell neogenesis, replication and dedifferentiation represent alternative sources of β-cell heterogeneity. In addition to a physiological role, β-cell heterogeneity influences the development of diabetes mellitus and its response to treatment. Identifying phenotypic and functional markers to discriminate distinct β-cell subpopulations and the mechanisms underpinning their regulation is warranted to advance current knowledge of β-cell function and to design novel regenerative strategies that target subpopulations of β cells. In this context, the Wnt/planar cell polarity (PCP) effector molecule Flattop can distinguish two unique β-cell subpopulations with specific transcriptional signatures, functional properties and differential responses to environmental stimuli. In vivo targeting of these β‑cell subpopulations might, therefore, represent an alternative strategy for the future treatment of diabetes mellitus.

     

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