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    Program

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    9:00:  Welcome & introduction: Florence Niedergang and Fatah Ouaaz, Institut Cochin, Paris, France

     Introduction keynote lecture (Chairs :  Georges Bismuth, Florence Niedergang, Institut Cochin, Paris, France)

     Memory B cells. Jean-Claude Weill, Institut Necker Enfants Malades, Paris, France

     

    Session 1  -  Antigen capture and B-cell activation

     (Chairs : Armelle Blondelle, Institut Cochin, Paris, France , Flavia Castellano, Institut Mondor, Créteil, France)

    Force patterning controls BCR-mediated endocytosis at the immune synapse. Paolo Pierobon, Institut Curie, Paris, France

    B cell activation by dendritic cell regurgitation of antigen. Fatah Ouaaz, Institut Cochin, Paris, France

     

    Coffee break

     

    Session  2  - Germinal center formation and plasma cells differentiation

    (Chairs : Emmanuel Donnadieu, Institut Cochin, Paris, France, Paulo Vieira, Institut Pasteur, Paris, France)

    Spontaneous germinal centers and extra-follicular plasma cells in secretion of pathogenic antibody. Michael Carroll, Boston Children's Hospital, Harvard Medical School, USA

    New regulators of plasma cell biology. Marion Espeli, Hôpital Saint-Louis, Paris, France

     

    Lunch

     

    The roles  of Tfh and Th10 in human B cell help. Jacques Banchereau,The Jackson Laboratory for Genomic Medicine, Farmington, USA

     

    Session 3  -  B cells signaling and regulation in health and disease

    (Chairs : Fatah Ouaaz, Institut Cochin, Paris, France, Frédéric Davi, Hôpital Pité-Salpêtrière, Paris, France)

    Signaling events underlying B-cell activation and lymphoma development. Margot Thome-Miazza, University of Lausanne, Switzerland

    Antibody-independent functions of plasma cells: a focus on their suppressive activities. Simon Fillatreau, IMAGINE, Paris, France

     

    Coffee break

     

    Session 4     Antibody-based therapies

    (Chairs : Philippe Grimbert, Hôpital Henri-Mondor, Créteil, France, Pierre-Régis Burgel, Institut et Hôpital Cochin, Paris, France)

    Impact of therapeutic monoclonal antibodies on host adaptive immunity. Sophie Sibéril, Centre de recherche des Cordeliers, Paris, France

     

    Closing remarks & celebration of the 10th anniversary

    Pierre-Olivier Couraud, Florence Niedergang, Fatah Ouaaz, Institut Cochin, Paris, France)