Thursday, November 14th

13:00-13:15    Welcome. Florence Niedergang (director of Institut Cochin, Paris, France),  Florian Britto, Pascal Maire, Benoit Viollet (organizers)

Session 1 - Inter-cellular and inter-organ communications in physiopathology
Chaired by Catherine Postic, Thierry Launay, Iryna Pirozhkova

13:15-14:00    Keynote: Bente Pedersen (University of Copenhagen, Denmark) - Exercise as medicine: focus on myokines
14:00-14:30    Jennifer Arrondeau (ENMC, UMR 8251, Paris, France) - Effect of physical activity on glucose uptake by cancer tumors: “MUSCULOPET study”
14:30-15:00    Jacob Smith (University of Barcelona, Spain) - Circadian rhythms in muscle-liver crosstalk
15:00-15:30    Benedicte Chazaud (INMG, Lyon, France) - The regenerative niche for skeletal muscle regeneration after exercise-induced muscle injury

Break

Session 2 - From pluripotent stem cells to skeletal muscle adaptation limits
Chaired by Athanassia Sotiropoulos, Glenda Comai, Pascal Maire

16:15-17:00    Keynote: Olivier Pourquié (Harvard Medical School, USA) - Deconstructing human skeletal muscle development in vitro
17:00-17:30    François Goldwasser (Hôpital Cochin & Institut Cochin, Paris, France)  - Host metabolism and antitumour immunotherapy
17:30-18:00    Angèle Merlet (Université Saint Etienne, France) - Exercise therapy: what effect on physical fitness and skeletal muscle tissue? Example of sickle cell disease and perspectives in other pathologies
18:00-18:30    Christophe Handschin (Biozentrum, University of Basel, Switzerland) - The multicellular mechanistic underpinnings of exercise adaptation in skeletal muscle

18:30-18:50    Meeting with Olympic athletes
19:00-20:30    Cocktail/diner - Cloitre Port-Royal

Friday, November, 15th

Session 3 - Muscle activity, neuromuscular diseases and therapy
Chaired by Anne Houdusse, Isabelle Richard, Benoit Viollet

09:00-09:45    Keynote: Helen Blau (Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, US) - Forget the exercise, take a pill

09:45-10:15   Serge Braun (AFM-Téléthon, EVRY, France)  - Gene therapy of neuromuscular diseases and potential impact of muscle exercise on therapeutic efficacy

10:15-10:45    Olivier Biondi (Université Evry Paris Saclay, France) - Precision exercise in neuromuscular disorders: disease-specific adaptations on mouse models

Break

Session 4 - Muscle activity, neuromuscular diseases, and aging
Chaired by Delphine Duprez, Frédéric Relaix, Sabrina Pichon

11:15-11:45    Patricia Thoreux (CIMS, Hôpital Hôtel Dieu – HUPC, Paris, France) and Pascal Laforet (Paris Saclay University, France) - Neuromuscular diseases and physical activity: what to think about in 202411:45-12:15    Laurent Schaeffer (INMG, Lyon, France) - Chromatin, DNA repair and muscle aging

12:15-12:45    Jerome Feige (Nestlé Institute of Health Sciences S.A., Lausanne, Switzerland) - Mitochondrial Calcium Import Regulates Performance and Aging of Skeletal Muscle
12:45-13:15    Florian Britto (Institut Cochin, Paris, France) - Influence of myofibers typology and metabolism on muscle hypertrophy

Lunch - Cloitre Port-Royal

Session 5 - Myofiber diversity, metabolism and physiopathology
Chaired by Capucine Trollet, Helge Amthor, Frédéric Bouillaud

14:45-15:30    Keynote: Marco Sandri (VIMM, University of Padua, Italy) - Novel insights linking mitochondria, bioenergetics, DNA damage and inflammation with sedentary life
15:30-16:00    Julien Ochala (University of Copenhagen, Copenhagen, Denmark) - Linking myosin to muscle metabolism
16:00-16:30    Kristian Gundersen (Institutt for Biovitenskap, Universitetet i Oslo, Norway) - What determines muscle fiber size?
16 :30-17:00   Jean-François Toussaint (IRMES,URP 7329, INSEP, Paris, France) - Olympism & paralympism: research, limits & development

18:00-19:00    Conférence grand public / General public lecture. Irène Margaritis (ANSES) 

• Pascal Maire, chercheur Inserm
• Benoit Viollet, chercheur Inserm
• Florian Britto, MCU Université Paris Cité
• Dominique Zeliszewski, chercheure CNRS

Une conférence sera donnée par Irène Margaritis (Unité d'évaluation des risques liés à la nutrition, ANSES) pour tout public, sur le thème Activité physique et nutrition. 

Les inscriptions seront gratuites mais obligatoires, et indépendantes des inscriptions au symposium scientifique.