Role of tissue-resident FOLR2+ macrophages as organizers of the tumor immune microenvironment

Tumor infiltrating macrophages play various pro-tumorigenic functions. However, it is now well established that various macrophage subsets with distinct functional properties co-exist within tumors. The goal of the FOLOME project is to explore the role of a mammary gland-resident macrophage subset located near blood vessels and interacting with anti-tumor cytotoxic T cells. Understanding the precise role played by this macrophage population could pave the way for the development of new immunotherapies to treat cancer.