Our intestinal tract is colonized by a complex community of microorganisms, named microbiota, which is playing numerous beneficial roles. However, uncontrolled microbiota can lead to detrimental impacts on its host by promoting chronic intestinal inflammation and associated diseases. In our laboratory, we are investigating how the intestinal microbiota is regulated by environmental factors, such as food additives (Axis 1), as well as how the host and its microbiota communicate (Axis 2). We are also exploring innovative ways to beneficially modulate the intestinal microbiota in order to promote health (Axis 3).