Alumni
Collaborations
Internal:
Florence MARGOTTIN-GOGUET
Véronique AVETTAND-FENOEL
Local:
-Stéphane EMILIANI - Institut Cochin
National:
-Gael CRISTOFARI - IRCAN Nice
International:
-Maike HANSEN - Radbud University - NED
Our work
Recently, The group of Roy Matkovic discovered a new mechanism of gene silencing in human cells that connects epigenetic silencing and RNA degradation: HUSH interacts with CNOT1, the nuclear RNA exosome, to induce degradation of RNA transcription from the HIV-1 LTR, while also promoting heterochromatinization of the provirus through H3K9me3 propagation (Matkovic et al, Nature Communications 2022). This novel type of gene expression repression mechanism in mammals demonstrates a close link between RNA metabolism and transcriptional gene repression.
The research group led by Roy MATKOVIC aims to understand, using biochemical, genetic, epigenetic, and molecular approaches, the interplay between the HIV-1 genomic RNA, Long non coding RNAs in building macromolecular complexes to prevent HIV-1 expression, leading to latency.
Publications
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
Matkovic R✉, Morel M, Lanciano S, Larrous P, Martin B, Bejjani F, Vauthier V, Hansen MMK, Emiliani S, Cristofari G, Gallois-Montbrun S, Margottin-Goguet F✉.
Nat Commun. 2022 Jan 10;13(1):66. doi: 10.1038/s41467-021-27650-5. (✉: co-corresponding)
HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819.
Vauthier V, Lasserre A, Morel M, Versapuech M, Berlioz-Torrent C, Zamborlini A, Margottin-Goguet F✉, Matkovic R✉. Retrovirology. 2022 Oct 29;19(1):23. doi: 10.1186/s12977-022-00610-7 (✉ : co-corresponding)
Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx.
Martin MM*, Matkovic R*, Larrous P, Morel M, Lasserre A, Vauthier V, Margottin-Goguet F. PLoS Pathogens 2021 Oct 26;17(10):e1009609. doi: 10.1371/journal.ppat.1009609. (*: co-first)
HIV-2/SIV viral protein X counteracts HUSH repressor complex.
Chougui G, Munir-Matloob S, Matkovic R, Martin MM, Morel M, Lahouassa H, Leduc M, Ramirez BC, Etienne L, Margottin-Goguet F. Nat Microbiol. 2018 Aug;3(8):891-897. doi: 10.1038/s41564-018-0179-6.
